Department of Surgery Research Seed Grant Presentations (March 27, 2024)

Needs Statement

Surgeons, advanced practice providers, fellows, residents, and medical students in various surgical specialties and subspecialties need to receive regular updates on advances in surgical care and clinical practices. Novel technologies and procedures will be examined as means to improve the diagnosis and treatment of medical conditions requiring surgical intervention. The series aims to expand the knowledge of learners, enhance surgical skills, increase surgical efficiency, disseminate surgical best practices, and improve surgical outcomes.

Target Audience

Physicians, medical students, fellows, and residents.

Learning Objectives

Multiplexed CRISPRa to Promote Mitochondrial Biogenesis in Cardiomyocytes
At the conclusion of the activity, the participants should be able to:
  • Recognize how clustered regularly interspaced short palindromic repeats activation (CRISPRa) can be utilized to modulate gene expression.
  • Describe the role energetics play in heart failure.
  • Identify tools that can be used to measure mitochondrial function.
Kidney Health Assessment in Mechanical Circulatory Support with Urine Exosomes
At the conclusion of the activity, the participants should be able to:
  • Recognize the current scenario and challenges in mitigating the rapid progression of kidney dysfunction in heart failure patients with durable mechanical circulatory assist device support.
  • Acknowledge that urine exosome protein quantification is a feasible method for non-invasive assessment of kidney cellular health status in heart failure patients prior to and after mechanical circulatory assist device implantation.
  • Utilize knowledge gained that will contribute to precision nephrology’s ultimate goals of precisely estimating kidney risk, identifying mechanistic pathways for intervention, and monitoring the biologic effects of interventions.
Probing Lipid Metabolism Associated with Resistance to Immune Checkpoint Blockade Therapies in Triple Negative Breast Cancer Tissues
At the conclusion of the activity, the participants should be able to:
  • Recognize basic principles of mass spectrometry imaging for rapid molecular analysis of tissues.
  • Evaluate molecular changes in breast cancer tissues associated with immune checkpoint therapies.
  • Identify new opportunities to use mass spectrometry to investigate molecular changes in tissues associated with treatment.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation
Course opens: 
Course expires: 

Baylor College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Baylor College of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation


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